Co-amorphous systems for the delivery of poorly water-soluble drugs: recent advances and an update. (2nd October 2020)

• Record Type: Journal Article
• Authors: Han, Jiawei; Wei, Yuanfeng; Lu, Yan; Wang, Runze; Zhang, Jianjun; Gao, Yuan; Qian, Shuai
• Is Part Of: Expert opinion on drug delivery. Volume 17:Number 10(2020)
• Page Start: 1411
• Page End: 1435
• Publication Date: 2020-10-02
• Subjects: Co-amorphous -- classification -- co-formers selection -- preparation -- physicochemical characteristics -- bioavailability; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2020.1796631
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Most new drug candidates under development are poorly water-soluble, which are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by the improvement of solubility/dissolution has become a major concern to develop efficacious drugs with reasonable dosing regimens for patients. Over the past decade, increasing reports have been published on the investigation of co-amorphous drug delivery systems, with positive and excited outcomes in improving in vitro and in vivo performances of poorly water-soluble drugs. Areas covered: This review summarizes recent findings of co-amorphous systems and provides their updates as a comprehensive overview in terms of classification, co-formers selection, preparation methods, physicochemical characteristics and in vivo performances. Expert opinion: Co-amorphous system, a homogeneous single-phase system containing two compatible drugs or a drug with a pharmaceutically acceptable small-molecule co-former, has been employed as a promising formulation technology to improve in vitro and in vivo performances of poorly water-soluble drugs such as solubility/dissolution, stability, mechanical properties and bioavailability. Furthermore, a deeper understanding of co-amorphous systems, including its detailed classification, the criteria of co-former selection, stability mechanisms and the faced challenges as well as perspectives, will be more conducive to its development and application.