Acute toxicity and health effect of perfluoroisobutyronitrile on mice: a promising substitute gas-insulating medium to SF6. Issue 14 (14th October 2020)

• Record Type: Journal Article
• Authors: Zhang, Xiaoxing; Ye, Fanchao; Li, Yi; Tian, Shuangshuang; Xie, Baojuan; Gao, Yadong; Xiao, Song
• Is Part Of: Journal of environmental science and health. Volume 55:Issue 14(2020)
• Page Start: 1646
• Page End: 1658
• Publication Date: 2020-10-14
• Subjects: Perfluoroisobutyronitrile -- inhalation toxicity -- gender differences -- physiological recovery characteristics -- engineering application; Environmental engineering -- Periodicals; Environmental sciences -- Periodicals; Ecology -- periodicals; Hazardous Substances -- periodicals; 628
• DOI: 10.1080/10934529.2020.1830654
• Languages: English
• ISSNs: 1093-4529

Abstract

Abstract: Perfluoroisobutyronitrile (C4 F7 N) is a new eco-friendly gas insulation medium that has potential to replace the most greenhouse gas sulfur hexafluoride (SF6 ) used in power industry. In order to ensure the engineering application safety, an in-depth assessment of the acute inhalation toxicity of C4 F7 N gas mixture is required. This article revealed gender differences in male and female mice after exposure to C4 F7 N and the physiological recovery characteristics of surviving mice by means of 4 h acute inhalation toxicity tests, hematological determinations and histopathological examination. Comparative analysis on the toxicity of C4 F7 N on mice and rats is also evaluated. We find that the LC50 of C4 F7 N for male and female mice is 1175 ppm (4 h), 1380 ppm (4 h) and female ones are more tolerant to C4 F7 N. Mice that exposed to 1000 ppm C4 F7 N for 4 h could survive and return to their normal state after the 14-day observation period without irreversible damage. The toxic effect duration of C4 F7 N on rats is longer than that of mice. Relevant results revealed the acute inhalation toxicity of C4 F7 N systematically and provided fundamental reference for inhalation safety protection and engineering application.