Development and implementation of common data elements for venous thromboembolism research: on behalf of SSC Subcommittee on official Communication from the SSC of the ISTH. (6th January 2021)

• Record Type: Journal Article
• Authors: Le Gal, Grégoire; Carrier, Marc; Castellucci, Lana A.; Cuker, Adam; Hansen, John‐Bjarne; Klok, Frederikus A.; Langlois, Nicole J.; Levy, Jerrold H.; Middeldorp, Saskia; Righini, Marc; Walters, Sam
• Other Names: Klok Erik investigator.; Bauman Kreuziger Lisa investigator.; Schulman Sam investigator.; Skeith Leslie investigator.; Zakai Neil investigator.; Riva Nicoletta investigator.; Douxfils Jonathan investigator.; Kahn Susan investigator.; Ten Cate‐Hoek Arina investigator.; Konstantinides Stavros investigator.; Ghanima Waleed investigator.; Lang Irene investigator.; Galanaud Jean‐Philippe investigator.; Moumneh Thomas investigator.; Gandara Esteban investigator.; Prandoni Paolo investigator.; Witmer Char investigator.; Lazo‐Langner Alejandro investigator.; Robert‐Ebadi Helia investigator.; Ní Áinle Fionnuala investigator.; Wu Cynthia investigator.; Wang Tzu‐Fei investigator.; Zwicker Jeffrey investigator.; Lauw Mandy investigator.; Ay Cihan investigator.; Maus Gabriela Cesarman investigator.; Angchaisuksiri Pantep investigator.; Steiner Marie investigator.; Bartz Raquel investigator.; Connors Jean investigator.; Samama Marc investigator.; Spyropoulos Alex investigator.; Faraoni David investigator.; Iba Toshiaki investigator.; Kearon Clive investigator.; Canniegeter Suzanne investigator.; Morange Pierre investigator.; Brækkan Sigrid investigator.; Morelli Vania investigator.; Orsi Fernanda investigator.;
• Is Part Of: Journal of thrombosis and haemostasis. Volume 19:Number 1(2021)
• Page Start: 297
• Page End: 303
• Publication Date: 2021-01-06
• Subjects: analysis -- data -- clinical research -- common data elements -- standardization -- venous thromboembolism; Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.15138
• Languages: English
• ISSNs: 1538-7933

Abstract

Abstract: Clinical research in venous thromboembolism (VTE) is hindered by variability in the collection and reporting of data and outcomes. A consistent data language facilitates efficiencies, leads to higher quality data, and permits between‐study comparisons and evidence synthesis. The International Society on Thrombosis and Haemostasis (ISTH) launched an international task force of more than 50 researchers to develop common data elements for clinical research in venous thromboembolism. The project was organized in seven working groups, each focusing on a topic area: General Core Data Elements; Anticoagulation and Other Therapies; Chronic VTE and Functional Outcomes; Diagnosis of VTE; Malignancy; Perioperative; and Predictors of VTE. The groups met via teleconference to collaboratively identify key data elements and develop definitions and data standards that were structured in a project‐specific taxonomy. A Steering Committee met by teleconference and in‐person to determine the overall scope of the project and resolve questions arising from the working groups. ISTH held an open public comment period to enable broader stakeholder involvement and feedback. The common data elements were then refined by the working groups to create a set of 512 unique data elements that are publicly available at http://isth.breakthrough.healthcare . The ISTH VTE Common Data Elements are intended to be a living project with ongoing curation, future expansion, and adaptation to meet the needs of the thrombosis and hemostasis research community.