A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus. (7th May 2017)

• Record Type: Journal Article
• Authors: Parrott, Jessica; Tener, Mitch; Dennis, Katie; Sharpe, Matthew; Clark-Ganheart, Cecily
• Other Names: Rasmussen Svein Academic Editor.
• Is Part Of: Case reports in obstetrics and gynecology. Volume 2017(2017)
• Publication Date: 2017-05-07
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; Obstetrics; Gynecology; Genital Diseases, Female; Generative organs, Female -- Diseases; Gynecology; Obstetrics; Electronic journals; Periodicals; Periodicals; 618
• DOI: 10.1155/2017/3547242
• Languages: English
• ISSNs: 2090-6684

Abstract

Abstract : Background . Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. Case . A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. Conclusion . The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity.