Clinical relevance of insulin-like growth factor-1 to cardiovascular risk markers. (4th December 2020)

• Record Type: Journal Article
• Authors: Harada, Ko; Hanayama, Yoshihisa; Obika, Mikako; Itoshima, Koichi; Okada, Ken; Otsuka, Fumio
• Is Part Of: Aging male. Volume 23:Number 5(2020)
• Page Start: 1030
• Page End: 1038
• Publication Date: 2020-12-04
• Subjects: Insulin-like growth factor-1 -- somatopause -- anemia -- inflammatory markers -- fibrin-related markers; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2019.1657083
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Objective: Insulin-like growth factor-1 (IGF-1) is an anabolic hormone, the levels of which decline with age. The present study aimed to determine the impact of age-related declines in serum IGF-1 levels on various physiological processes. Design: We retrospectively reviewed the medical records of patients whose serum IGF-1 levels were estimated in our department, and assessed the relationships between serum IGF-1 levels and various physiological parameters. Results: A total of 427 patients with a mean (± standard deviation) age of 52.8 (± 17.1) years were included in the analysis. The levels of serum IGF-1 showed significant positive correlation with those of hemoglobin and hematocrit, and negative correlation with the presence of inflammatory and fibrin-related markers including C-reactive protein (CRP) and procalcitonin (PCT), and D-dimer and fibrin degradation products (FDP). These tendencies persisted after exclusion of patients with pituitary disease. Conclusions: In this study population of diverse diseases and backgrounds, a decline in serum IGF-1 levels with age was associated with an increase in inflammatory and fibrin-related markers. This may explain the correlation between low serum IGF-1 levels and an increased risk of cardiovascular events. Our findings suggest that serum IGF-1 is a clinically relevant marker of cardiovascular risk, particularly in males.