Investigation of ultrasonic soft tissue-bone reflection coefficients correlating with curve severity in children with adolescent idiopathic scoliosis. (September 2022)

• Record Type: Journal Article
• Authors: Pham, Thanh-Tu; Le, Lawrence H; Khodaei, Mahdieh; Zheng, Rui; Lou, Edmond
• Is Part Of: Proceedings of the Institution of Mechanical Engineers. Volume 236:Number 9(2022)
• Page Start: 1403
• Page End: 1413
• Publication Date: 2022-09
• Subjects: Adolescent idiopathic scoliosis -- ultrasound reflection coefficient -- bone quality -- curve severity -- correlation; Biomedical engineering -- Periodicals; Medical instruments and apparatus -- Periodicals; 610.28
• DOI: 10.1177/09544119221114200
• Languages: English
• ISSNs: 0954-4119

Abstract

Adolescent idiopathic scoliosis (AIS) is a three-dimensional curvature of spine. Children with AIS and low bone quality have higher chance to get curve progression leading to bigger spinal curvature. In addition, bone quality affects acoustic impedance of bone, thus influencing the reflection coefficient of ultrasound signal from the soft tissue–bone interface. This study aimed to estimate the bone quality of AIS patients based on the reflection coefficients to determine the correlation of the bone quality with curve severity. A simple bone model was used to develop an equation to calculate the reflection coefficient value. Experiments were conducted on five different phantoms. Acrylic was used to design a vertebral shape to study the effect of surface roughness and inclination, including: smooth flat surface (SFS), smooth curved surface (SCS), rough curved surface (RCS), and the rough curved inclined surface (RCIS). A clinical study with 37 AIS patients were recruited. The estimated reflection coefficient values of plate phantoms agreed well with the predicted values and the maximum error was 6.7%. The reflection coefficients measured from the acrylic-water interface for the SFS, SCS, RCS, RCIS (3° and 5°) were 0.37, 0.33, 0.28, (0.23 and 0.12), respectively. The surface roughness and inclination increased the reflection loss. From the clinical data, the average reflection coefficients for children with AIS were 0.11 and 0.07 for the mild curve group and the moderate curve group, respectively. A moderate linear correlation was found between the reflection coefficients and curve severity (r 2 = 0.3). Patients with lower bone quality have observed to have larger spinal curvature.