Empty Nose Syndrome Pathophysiology: A Systematic Review. (September 2022)

• Record Type: Journal Article
• Authors: Kanjanawasee, Dichapong; Campbell, Raewyn G.; Rimmer, Janet; Alvarado, Raquel; Kanjanaumporn, Jesada; Snidvongs, Kornkiat; Kalish, Larry; Harvey, Richard J.; Sacks, Raymond
• Is Part Of: Otolaryngology--head and neck surgery. Volume 167:Number 3(2022)
• Page Start: 434
• Page End: 451
• Publication Date: 2022-09
• Subjects: empty nose syndrome -- nasal perception -- psychogenic comorbidity -- neurogenic dysfunction; Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/01945998211052919
• Languages: English
• ISSNs: 0194-5998

Abstract

Objective: The pathophysiology of empty nose syndrome (ENS) remains unclear despite significant research. The pathophysiologic mechanism of ENS was systematically reviewed. Data Sources: MEDLINE and Embase. Review Methods: Data were systematically reviewed for studies that provided original data on pathophysiology. Results: A total of 2476 studies were screened, and 19 met the inclusion criteria: 13 case-control and 6 cross-sectional. Nine pathophysiologic themes were identified. Demographics: ENS symptoms had no relationship with climatic factors. Symptomatology: ENS patients demonstrated high symptom severity. Mental health: Anxiety and depression including hyperventilation were reported in >50% of ENS patients and correlated with ENS symptom severity. Anatomic features: Structural changes in response to turbinate surgery were similar between ENS and non-ENS patients. Airflow analysis: Airflow parameters were similar between ENS and non-ENS patients after turbinate surgery. On computational fluid dynamic analysis, differences were found on multiple outcomes. Diagnostic testing: The menthol detection test was impaired in ENS, and cotton placement in the airway improved ENS symptoms. Cognitive function: Functional magnetic resonance imaging showed activation in emotional processing area during breathing. Olfactory function: Subjective impairment was reported in ENS, but quantitative measures were similar to non-ENS patients. Mucosal physiology/innate immunity: Turbinate histopathology in ENS showed a tissue-remodeling pattern. Nasal nitric oxide level was lower in ENS patients. Conclusion: There is evidence of high comorbid mental health disorders in ENS patients. An abnormal trigeminal-thermoreceptor response may be present in some patients. The influence of altered airflow and the evidence of surgery as the cause for ENS are unclear.