A Case of Brain Abscess Caused by Medication-Related Osteonecrosis of the Jaw. (2nd February 2016)

• Record Type: Journal Article
• Authors: Yamagata, Kenji; Nagai, Hiroki; Baba, Osamu; Uchida, Fumihiko; Kanno, Naomi; Hasegawa, Shogo; Yanagawa, Toru; Bukawa, Hiroki
• Other Names: Arduino Paolo Giacomo Academic Editor.
• Is Part Of: Case reports in dentistry. Volume 2016(2016)
• Publication Date: 2016-02-02
• Subjects: Dentistry -- Case studies -- Periodicals; Oral medicine -- Case studies -- Periodicals; Oral Medicine; Dentistry; Dentistry; Oral medicine; Electronic journals; Periodical; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 617.6
• DOI: 10.1155/2016/7038618
• Languages: English
• ISSNs: 2090-6447

Abstract

Abstract : Reports of brain abscesses caused by medication-related osteonecrosis of the jaw (MRONJ) are very rare. We here present the case of a 76-year-old man with terminal-stage prostatic carcinoma and a brain abscess caused by MRONJ at the maxilla. The patient had been treated with zoledronic acid and denosumab for bone metastasis. For the brain abscess, an antibiotic regimen based on ceftriaxone and metronidazole and a sequestrectomy contributed to a successful outcome. In the case of maxillary MRONJ extending to the maxillary sinus, active resection of the infected bone should be considered to prevent the spread of the infection beyond the maxillary sinus, into the ethmoid sinus, and into the brain.