Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China. Issue 1 (1st January 2019)

• Record Type: Journal Article
• Authors: Li, Xiaoyan; Guo, Liru; Liu, Caixia; Cheng, Yanhui; Kong, Mei; Yang, Lei; Zhuang, Zhichao; Liu, Jia; Zou, Ming; Dong, Xiaochun; Su, Xu; Gu, Qing
• Is Part Of: Emerging microbes & infections. Volume 8:Issue 1(2019)
• Page Start: 1535
• Page End: 1545
• Publication Date: 2019-01-01
• Subjects: Influenza A virus -- EAS-H1N1 -- triple-reassortant -- molecular characteristics -- Phylogenetic analysis; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1080/22221751.2019.1679611
• Languages: English
• ISSNs: 2222-1751

Abstract

ABSTRACT: Influenza A virus infections occur in different species, causing mild to severe respiratory symptoms that lead to a heavy disease burden. Eurasian avian-like swine influenza A(H1N1) viruses (EAS-H1N1) are predominant in pigs and occasionally infect humans. An influenza A(H1N1) virus was isolated from a boy who was suffering from fever and headache and designated as A/Tianjin-baodi/1606/2018(H1N1). Full-genome sequencing and phylogenetic analysis revealed that A/Tianjin-baodi/1606/2018(H1N1) is a novel reassortant EAS-H1N1 containing gene segments from EAS-H1N1 (HA and NA), classical swine H1N1(NS) and A(H1N1)pdm09(PB2, PB2, PA, NP and M) viruses. The isolation and analysis of A/Tianjin-baodi/1606/2018(H1) provide further evidence that EAS-H1N1 poses a threat to human health and greater attention should be paid to surveillance of influenza virus infection in pigs and humans.