Nilotinib-Associated Destructive Thyroiditis. (7th May 2015)

• Record Type: Journal Article
• Authors: Bakerywala, Suhalia; Schwarcz, Monica D.; Goldberg, Michael D.; Valiquette, Guy; Weiss, Irene A.
• Other Names: Simsek Suat Academic Editor.
• Is Part Of: Case reports in endocrinology. Volume 2015(2015)
• Publication Date: 2015-05-07
• Subjects: Endocrinology -- Periodicals; Endocrinology -- Case studies -- Periodicals; Endocrine glands -- Diseases -- Periodicals; Endocrinology; Endocrine System Diseases; Endocrine glands -- Diseases; Endocrinology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.4
• DOI: 10.1155/2015/736092
• Languages: English
• ISSNs: 2090-6501

Abstract

Abstract : Protein tyrosine kinase inhibitors are currently an important drug class in the treatment of leukemia. They represent targeted cancer therapy and have become the treatment of choice in chronic myeloid leukemia. Tyrosine kinases are enzymes expressed in multiple tissues and are involved in several signaling pathways influencing cellular growth. Below we describe a patient who developed an unusual complication of tyrosine kinase inhibitor therapy: thyrotoxicosis due to destructive thyroiditis. We review the pathophysiology of tyrosine kinase inhibitor-induced thyroid dysfunction particularly with regard to new second-generation tyrosine kinase inhibitors.