Long-Term Intravenous Ketamine for Analgesia in a Child with Severe Chronic Intestinal Graft versus Host Disease. (8th December 2015)

• Record Type: Journal Article
• Authors: Busse, Jennifer; Phillips, Leroy; Schechter, William
• Other Names: Yang Jian-jun Academic Editor.
• Is Part Of: Case reports in anesthesiology. Volume 2015(2015)
• Publication Date: 2015-12-08
• Subjects: Anesthesiology -- Periodicals; 617.9605
• DOI: 10.1155/2015/834168
• Languages: English
• ISSNs: 2090-6382

Abstract

Abstract : Ketamine is reported to be an effective adjuvant to opioids in the treatment of refractory cancer pain; however, the use of high doses of ketamine for extended periods in pediatric patients has not been described. We present a five-year-old male with grade IV intestinal GVHD whose abdominal pain required both hydromorphone and ketamine for a period of over four months. There was no evidence of hepatotoxicity, hemorrhagic cystitis, or other adverse effects. Possible withdrawal symptoms were mild and were readily mitigated by gradually weaning ketamine.