Management of Liddle Syndrome in Pregnancy: A Case Report and Literature Review. (15th March 2017)

• Record Type: Journal Article
• Authors: Awadalla, Michael; Patwardhan, Manasi; Alsamsam, Adham; Imran, Nashat
• Other Names: Geary Michael Academic Editor.
• Is Part Of: Case reports in obstetrics and gynecology. Volume 2017(2017)
• Publication Date: 2017-03-15
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; Obstetrics; Gynecology; Genital Diseases, Female; Generative organs, Female -- Diseases; Gynecology; Obstetrics; Electronic journals; Periodicals; Periodicals; 618
• DOI: 10.1155/2017/6279460
• Languages: English
• ISSNs: 2090-6684

Abstract

Abstract : Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension. We report a case of a 27-year-old pregnant woman who was admitted for hypertension and hypokalemia and later diagnosed and treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle syndrome in pregnancy is essential in such cases to be able to adequately and effectively treat the hypertension. Due to physiological effects of pregnancy, the dose of amiloride may need to be increased as gestational age progresses up to a maximum dose of 30 mg orally per day.