Drug Hypersensitivity due to Azathioprine with Elevated Procalcitonin. (10th June 2018)

• Record Type: Journal Article
• Authors: Ahuja, Tania; Chung, Frank R.; Ruiz-Maya, Tania
• Other Names: Firooz Alireza Academic Editor.
• Is Part Of: Case reports in dermatological medicine. Volume 2018(2018)
• Publication Date: 2018-06-10
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1155/2018/2648325
• Languages: English
• ISSNs: 2090-6463

Abstract

Abstract : We present a case of azathioprine hypersensitivity presenting as sepsis with elevated procalcitonin in a 68-year-old man with myasthenia gravis. The patient presented with fever, chills, nausea, vomiting, and headache. He developed numerous 1 cm erythematous papules over his upper torso. Infectious workup including bacteriological tests and microbial cultures was negative and a skin biopsy was performed which revealed suppurative folliculitis with eosinophils, consistent with drug hypersensitivity. Notably, acute phase reactants including C-reactive protein and procalcitonin were elevated upon presentation, likely secondary to drug hypersensitivity.