Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism. (May 2021)

• Record Type: Journal Article
• Authors: Haze, Tatsuya; Hirawa, Nobuhito; Yano, Yuichiro; Tamura, Kouichi; Kurihara, Isao; Kobayashi, Hiroki; Tsuiki, Mika; Ichijo, Takamasa; Wada, Norio; Katabami, Takuyuki; Yamamoto, Koichi; Oki, Kenji; Inagaki, Nobuya; Okamura, Shintaro; Kai, Tatsuya; Izawa, Shoichiro; Yamada, Masanobu; Chiba, Yoshiro; Tanabe, Akiyo; Naruse, Mitsuhide
• Is Part Of: Atherosclerosis. Volume 324(2021)
• Page Start: 84
• Page End: 90
• Publication Date: 2021-05
• Subjects: Primary aldosteronism -- Hypertension -- Cardiovascular disease -- Aldosterone -- Renin -- Blood pressure -- Pulse pressure; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2021.03.033
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: We used a dataset from a Japanese nationwide registry of patients with primary aldosteronism, to determine which of the parameters of hyperaldosteronism and blood pressure before or after treatments for primary aldosteronism (i.e., surgical adrenalectomy or a medication treatment) are important in terms of cardiovascular prognosis. Methods: We assessed whether plasma aldosterone-to-renin ratio and pulse pressure levels before treatment and 6 months after treatment were associated with composite cardiovascular disease events during the 5-year follow-up period. Results: The cohort included 1987 patients (mean age was 53.2 years, 52.0% were female, 37.2% had undergone surgical treatment, and the remainder had been treated with mineralocorticoid receptor antagonists). In the Cox proportional hazard model, the covariate-adjusted hazard ratio (95% confidence interval) for the composite cardiovascular disease events risk for each one-standard-deviation increase in the aldosterone-to-renin ratio or pulse pressure before treatment, those after treatment, or the duration of hypertension were 1.24 (1.05, 1.48), 0.74 (0.54, 1.02), and 1.07 (0.79, 1.44), 1.43 (1.07, 1.92), and 1.52 (1.19, 1.95), respectively. Patients with a high pre-treatment aldosterone-to-renin ratio of more than 603 and a large post-treatment pulse pressure of more than 49 mmHg showed approximately three-fold higher hazard ratios for cardiovascular events risk compared to those with a lower aldosterone-to-renin ratio and smaller pulse pressure. Conclusions: Higher aldosterone-to-renin ratio before treatments, higher pulse pressure after treatments, and longer duration of hypertension were prognostic factors for cardiovascular diseases. Early intervention may be important for preventing cardiovascular disease among patients with primary aldosteronism. Graphical abstract: Image 1 Highlights: Higher pulse pressure after treatments for primary aldosteronism (PA) was a risk factor for cardiovascular diseases (CVD). Our results suggest that the risk of CVD is associated with how arteriosclerosis progresses before initiating treatment. Early intervention may be important for preventing CVD among patients with PA.