Denosumab Therapy for Giant Cell Tumor of Bone Pulmonary Metastasis. (10th May 2017)

• Record Type: Journal Article
• Authors: Egbert, Ryan Carlisle; Folsom, Ryan; Bell, Jeff; Rajani, Rajiv
• Other Names: Ahlmann Elke R. Academic Editor.
• Is Part Of: Case reports in orthopedics. Volume 2017(2017)
• Publication Date: 2017-05-10
• Subjects: Orthopedics -- Periodicals; Orthopedics; Orthopedics; Periodicals; Electronic journals; Periodicals; 616.7
• DOI: 10.1155/2017/2302597
• Languages: English
• ISSNs: 2090-6749

Abstract

Abstract : Case . A 68-year-old female was diagnosed with giant cell tumor of bone (GCTB) metastatic to her lungs. The patient was treated with IV denosumab for the course of 4.5 years for these metastases. The metastatic tumor burden decreased significantly after only 3 months of therapy. The size of the metastases has been stable for over 4 years. Conclusion . Denosumab therapy has promise in the treatment of GCTB, including pulmonary metastasis. However, the long-term role of denosumab for pulmonary metastases is yet to be determined.