Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats. Issue 3 (2010)

• Record Type: Journal Article
• Authors: Kumar, Vishnu; Khan, Mohammad Mubin; Khanna, Ashok Kumar; Singh, Ranjana; Singh, Sushma; Chander, Ramesh; Mahdi, Farzana; Mahdi, Abbas Ali; Saxena, Jitendra Kumar; Singh, Raj Kumar
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 7:Issue 3(2010)
• Page Start: 317
• Page End: 322
• Publication Date: 2010
• Subjects: Anthocephalus indicus -- hypolipidemic agent -- oxygen free radical scavengers -- plant antioxidant -- Rubiaceae -- triton model of hyperlipidemia; Alternative medicine -- Periodicals; 615.505
• DOI: 10.1093/ecam/nen001
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg −1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro . The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.