Albumin-mediated extracellular zinc speciation drives cellular zinc uptake. Issue 53 (13th June 2022)
- Record Type:
- Journal Article
- Title:
- Albumin-mediated extracellular zinc speciation drives cellular zinc uptake. Issue 53 (13th June 2022)
- Main Title:
- Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
- Authors:
- Coverdale, James P. C.
van den Berg, Hugo A.
Khazaipoul, Siavash
Bridgewater, Hannah E.
Stewart, Alan J.
Blindauer, Claudia A. - Abstract:
- Abstract : Fatty acids alter zinc speciation in plasma, increasing zinc influx into endothelial cells. Abstract : The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
- Is Part Of:
- Chemical communications. Volume 58:Issue 53(2022)
- Journal:
- Chemical communications
- Issue:
- Volume 58:Issue 53(2022)
- Issue Display:
- Volume 58, Issue 53 (2022)
- Year:
- 2022
- Volume:
- 58
- Issue:
- 53
- Issue Sort Value:
- 2022-0058-0053-0000
- Page Start:
- 7384
- Page End:
- 7387
- Publication Date:
- 2022-06-13
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d2cc02278h ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 22458.xml