Dietary daidzein decreases food intake accompanied with delayed gastric emptying in ovariectomized rats. Issue 6 (2nd June 2020)

• Record Type: Journal Article
• Authors: Adhikari, Sudhashree; Bhattarai, Keshab; Abe, Yasuhiro; Kira, Mayu; Fujitani, Mina; Miyada, Tomihiro; Kishida, Taro
• Is Part Of: Bioscience, biotechnology, and biochemistry. Volume 84:Issue 6(2020)
• Page Start: 1232
• Page End: 1238
• Publication Date: 2020-06-02
• Subjects: Daidzein -- anorectic effect -- gastric emptying; Biotechnology -- Periodicals; Biochemistry -- Periodicals; 660.6
• DOI: 10.1080/09168451.2020.1723404
• Languages: English
• ISSNs: 0916-8451

Abstract

ABSTRACT: We previously found that equol, a metabolite of intestinal bacterial conversion from soy isoflavone daidzein, has female-specific anorectic effects. In the present study, we used seven-week-old female ovariectomized (OVX) Sprague Dawley rats to test the hypothesis that the anorectic effect of dietary daidzein may be attributed to delayed gastric emptying. Results suggest that dietary daidzein delays gastric emptying and that it has an anorectic effect with residual gastric contents, but not without gastric contents. Dietary equol significantly decreased daily food intake in the OVX rats without sleeve gastrectomy, but not in those with sleeve gastrectomy, suggesting that the accumulation of food in the stomach is required for the anorectic effect of equol to occur. These results support the hypothesis that the anorectic effect of dietary daidzein is attributed to delayed gastric emptying. Graphical abstract: : Dietary daidzein delays gastric emptying, and has an anorectic effect with residual gastric contents, but not without gastric contents.