A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM. (15th June 2022)

• Record Type: Journal Article
• Authors: Wurzburger, Riana
• Other Names: Komatsu Haruki Academic Editor.
• Is Part Of: Case reports in hepatology. Volume 2022(2022)
• Publication Date: 2022-06-15
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; Liver Diseases; Liver; Liver; Liver -- Diseases; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.36
• DOI: 10.1155/2022/6331923
• Languages: English
• ISSNs: 2090-6587

Abstract

Abstract : Teriflunomide is a pyrimidine synthesis inhibitor used in the treatment of multiple sclerosis that has in rare instances been associated with liver toxicity, though there are few documented cases. Here, we report a case of probable teriflunomide-induced liver injury as assessed for causality using the updated RUCAM. The liver injury occurred approximately nine months after teriflunomide initiation and improved with discontinuation of the drug and treatment with cholestyramine.