Laparoscopic versus open transhiatal approach for adenocarcinoma of the esophagogastric junction: A systematic review and meta-analysis. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Chen, Xiao-Dong; He, Fu-Qian; Liao, Mao-Shan; Chen, Mi
• Is Part Of: European journal of surgical oncology. Volume 47:Issue 4(2021)
• Page Start: 778
• Page End: 788
• Publication Date: 2021-04
• Subjects: Adenocarcinoma of the esophagogastric junction -- Transhiatal approach -- Laparoscopic surgery -- Meta-analysis; AEG adenocarcinoma of the esophagogastric junction -- EGJ esophagogastric junction -- OTH open transhiatal approach -- LTH laparoscopic transhiatal approach -- RCTs randomized controlled trials -- TG total gastrectomy -- PG proximal gastrectomy -- MD mean difference -- RD risk difference -- RR risk ratio -- HR hazard ratio -- OS overall survival -- DFS disease-free survival -- RFS relapse-free survival -- PSM propensity score matching -- RCS retrospective cohort studies; Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2020.10.022
• Languages: English
• ISSNs: 0748-7983

Abstract

Abstract: Background: The incidence of adenocarcinoma of the esophagogastric junction (AEG) is increasing worldwide. Laparoscopic transhiatal approach (LTH) has gained growing popularity in the treatment of AEG. However, its safety and efficacy need to be evaluated. Methods: Original studies comparing LTH with open transhiatal approach (OTH) were searched. Meta-analysis was performed using RevMan 5.3. Results: Nine studies involving 2149 patients were eligible. Compared with OTH, LTH was associated with longer operation time (mean difference [MD] = 31min, 95%CI [20, 41], P < 0.001) while less blood loss (MD = −103ml [-135, −72], P < 0.001), and harvested similar number of lymph nodes (MD = 0.1 [-1.2, 1.4], P = 0.89). There were no differences in time to ambulation (MD = −0.79 days [-1.77, 0.20], P = 0.12) or time to first flatus (MD = −0.82 days [-1.76, 0.11], P = 0.08); however, LTH was associated with shorter postoperative hospital stay (MD = −1.70 days [-2.34, −1.05], P < 0.001). The mortality after surgery was comparable for LTH and OTH (risk difference [RD] = -0.00 [-0.01, 0.01], P = 0.55). The incidence of total major complications was similar in LTH (6.1%) and OTH (8.4%) (RD = −0.02 [-0.05, 0.01], P = 0.12); there were no significant differences in the incidence of each complication. Furthermore, LTH achieved similar 2-year overall survival (OS) rate (risk ratio [RR] = 1.17 [0.86, 1.60], P = 0.31) while higher 5-year OS rate (RR = 1.43 [1.18, 1.73], P = 0.0003) and significant improvement of OS (univariable hazard ratio = 0.65 [0.50, 0.84], P = 0.0009; multivariable hazard ratio = 0.59 [0.44, 0.80], P = 0.0006). Conclusions: LTH is feasible and safe for AEG, and may provide more favorable short-term outcomes and potential long-term survival benefit, which needs to be confirmed by randomized trials. Highlights: ● Laparoscopic transhiatal approach (LTH) for AEG has gained growing popularity. ● LTH may provide favorable surgical outcomes and potential survival benefit. ● Prospective randomized controlled trials are urgently needed.