A Case of Granuloma Annulare Associated with Secukinumab Use. (22nd May 2017)

• Record Type: Journal Article
• Authors: Bonomo, Lauren; Ghoneim, Sara; Levitt, Jacob
• Other Names: Bassukas Ioannis D. Academic Editor.
• Is Part Of: Case reports in dermatological medicine. Volume 2017(2017)
• Publication Date: 2017-05-22
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1155/2017/5918708
• Languages: English
• ISSNs: 2090-6463

Abstract

Abstract : Granuloma annulare (GA) is a benign inflammatory dermatosis characterized clinically by dermal papules and annular plaques. The pathogenesis of GA is not well understood, although it is thought to result from a delayed-type hypersensitivity reaction in which inflammatory cells elicit connective tissue degradation. This condition has been seen following the use of several drugs, including tumor necrosis factor-alpha (TNF-α ) inhibitors, which paradoxically have also been reported to treat GA. We report the case of a patient who developed GA in association with secukinumab, an interleukin-17A antagonist, and discuss its implications for our understanding of the pathogenesis of GA.