Surgery and dose-escalated radiotherapy for a de novo intracranial squamous cell carcinoma of the cerebellopontine angle. (March 2021)

• Record Type: Journal Article
• Authors: Mula-Hussain, Layth; Malone, Julia; dos Santos, Marlise P.; Alkherayf, Fahad; Sinclair, John; Malone, Shawn
• Is Part Of: Clinical and translational radiation oncology. Volume 27(2021)
• Page Start: 99
• Page End: 102
• Publication Date: 2021-03
• Subjects: Cancer -- Radiotherapy -- Periodicals; Oncology -- Periodicals; Cancer -- Radiotherapy; Oncology; Radiation Oncology; Neoplasms -- radiotherapy; Translational Medical Research; Periodicals; Electronic journals; Periodicals; 616.9940642
• DOI: 10.1016/j.ctro.2021.01.010
• Languages: English
• ISSNs: 2405-6308

Abstract

Highlights: De novo intracranial squamous cell carcinoma of the cerebellopontine angle is extremely rare. One has to consider it when facing a mass with multiple neurological deficits. Dose-escalated radiotherapy may help to achieve excellent and durable outcomes. Abstract: We report an extremely rare case of de novo intracranial squamous cell carcinoma of the cerebellopontine angle. The patient underwent craniotomy for debulking of the lesion to relieve mass effect on the brainstem and to establish a tissue diagnosis. Cancer staging revealed no other primary cancers and no evidence of metastatic disease. Postoperatively, he received image-guided intensity-modulated radiotherapy to the tumor bed followed by fractionated radiosurgery boost to the gross residual disease for a total average dose of 7000 cGy. He had a complete response to radiation and remains 42-months' disease-free post-treatment.