LI-RADS v2018 major criteria: Do hepatocellular carcinomas in non-alcoholic steatohepatitis differ from those in virus-induced chronic liver disease on MRI?. Issue 138 (May 2021)

• Record Type: Journal Article
• Authors: Barat, Maxime; Nguyen, Thi Thuy Linh; Hollande, Clémence; Coty, Jean-Baptiste; Hoeffel, Christine; Terris, Benoit; Dohan, Anthony; Mallet, Vincent; Pol, Stanislas; Soyer, Philippe
• Is Part Of: European journal of radiology. Issue 138(2021)
• Publication Date: 2021-05
• Subjects: CT computed tomography -- DWI diffusion-weighted imaging -- HBV hepatitis B virus -- HCC hepatocellular carcinoma -- HCV hepatitis C virus -- LI-RADS Liver Imaging Reporting and Data System -- MRI magnetic resonance imaging -- NAFLD non-alcoholic fatty liver disease -- NASH non-alcoholic steatohepatitis; Carcinoma, hepatocellular (Unique ID, D006528) -- Magnetic resonance imaging (Unique ID, D008279) -- Non-alcoholic fatty liver disease (Unique ID, D065626) -- Liver neoplasms (Unique ID, D008113); Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2021.109651
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: Hepatocellular carcinoma in non-alcoholic steatohepatitis shows MRI features similar to those of virus-induced chronic liver disease. The LIRADS v2018 major criteria have a high inter-reader agreement for hepatocellular carcinomas developing in non-alcoholic steatohepatitis. The LI-RADS v2018 major criteria can be applied in patients with non-alcoholic steatohepatitis. Abstract: Purpose: LI-RADS v2018 diagnostic system is used to diagnose hepatocellular carcinoma (HCC) in at risk patients. However, its applicability to HCC in non-alcoholic steatohepatitis (NASH) has not been specifically studied. The purpose of this study was to assess the applicability of LI-RADS v2018 diagnostic system for HCC in patients with NASH. Materials and methods: The MRI examinations of 41 patients with HCC and NASH (NASH group) were reviewed and compared to those obtained in 41 patients with HCC and virus-induced chronic liver disease (Virus group). MRI examinations of the two groups were compared for imaging presentation, LI-RADS major criteria and LI-RADS categorization. Qualitative variables were compared using Fisher exact test and quantitative variables using Mann-Whitney U test Interreader agreement was assessed using kappa statistic. Results: No significant differences in qualitative and quantitative variables were observed between the two groups. Most common findings in the two groups were hyperenhancement during the arterial phase and visibility on T2-weighted images (93 % vs . 98 %, P = 0.616 and 85 % vs . 88 %, P = 1.000 for NASH group and Virus group, respectively). No differences in prevalence between the two groups were found for any major LI-RADS v2018 criterion. Interreader agreement for LI-RADS categorization was strong for the NASH group (kappa = 0.802) and moderate for the virus group (kappa = 0.720). No differences were found between the two groups for LI-RADS categories ( P = 0.303). Conclusions: The LI-RADS v2018 diagnostic algorithm can be applied in patients with NASH.