Fenofibrate‐induced hepatotoxicity: A case with a special feature that is different from those in the LiverTox database. (13th September 2019)

• Record Type: Journal Article
• Authors: Ma, Shizhan; Liu, Shudong; Wang, Qi; Chen, Lijuan; Yang, Ping; Sun, Huihuan
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 45:Number 1(2020)
• Page Start: 204
• Page End: 207
• Publication Date: 2019-09-13
• Subjects: drug‐induced liver injury -- fenofibrate -- hepatotoxicity -- hypertriglyceridemia; Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.13042
• Languages: English
• ISSNs: 0269-4727

Abstract

Abstract: What is known and objective: We report a special case of fenofibrate‐induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. Case summary description: The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglyceridemia. Liver enzyme levels eventually declined to normal within two weeks after the discontinuation of fenofibrate. What is new and Conclusion: Early detection of elevated hepatic enzymes after fenofibrate initial treatment helps physicians to avoid delayed diagnosis and subsequent treatment. Abstract : we reported a case of fenofibrate‐induced acute liver injury with a special characteristic of sudden onset and rapid recovery, which is different from those in the LiverTox database.