CELL THERAPY IN INFLAMMATORY BOWEL DISEASE. (January 2021)

• Record Type: Journal Article
• Authors: Cassinotti, Andrea; Passamonti, Francesco; Segato, Sergio
• Is Part Of: Pharmacological research. Volume 163(2021)
• Publication Date: 2021-01
• Subjects: cell therapy -- mesenchymal stem cells -- haematopoietic stem cells -- T-reg -- IBD; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.105247
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical Abstract: Abstract: In recent years, cell-based therapies have been explored in various immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD). Cell therapy is the process of introducing new cells into an organism or tissue in order to treat a disease. The most studied cellular treatment in IBD was "stem cells-based therapy", which was explored according to different protocols in terms of type of donors, stem cells sources, study design and clinical endpoints. More recently, preliminary studies have also described the clinical use of "regulatory cells", which include T-reg and Tr1 cells, and "tolerogenic" dendritic cells. Finally, induced pluripotent stem cells are the subject of an intensive preclinical research program on animal models, including those related to colitis.