Patient reported outcome and cosmetic evaluation following implant-based breast-reconstruction with a titanized polypropylene mesh (TiLOOP® Bra): A prospective clinical study in 269 patients. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Thill, Marc; Faridi, Andree; Meiré, Anette; Gerber-Schäfer, Claudia; Baumann, Kristin; Blohmer, Jens-Uwe; Mau, Christine; Tofall, Sabrina; Nolte, Elke; Strittmatter, Hans-Joachim; Ohlinger, Ralf; Paepke, Stefan
• Is Part Of: European journal of surgical oncology. Volume 46:Issue 8(2020)
• Page Start: 1484
• Page End: 1490
• Publication Date: 2020-08
• Subjects: Patient-reported outcome -- Cosmetic outcome -- Breast reconstruction -- Surgical mesh; PRO-BRA National, multicenter post-market surveillance study 'Patient Reported Outcome' in BR following mastectomy with titaniferously coated polypropylene mesh (TiLOOP® Bra) -- 12mFU 12 months Follow-Up -- BR breast reconstruction -- PRO patient reported outcome -- AE adverse event -- pre-OP prior surgery -- SSM skin sparing mastectomy -- NAC nipple areolar complex -- NSSM nipple areolar complex sparing mastectomy; Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2020.04.009
• Languages: English
• ISSNs: 0748-7983

Abstract

Abstract: Introduction: Implant-based or expander-supported breast reconstruction is an established surgical method after mastectomies due to cancer or to prophylactic reasons. Patient reported outcome (PRO) and cosmetic outcome after breast reconstruction with a synthetic surgical mesh was investigated in a prospective, single-arm, multi-center study. Material and methods: Primary or secondary implant-based breast reconstruction with support of TiLOOP® Bra was performed in 269 patients during the PRO-BRA study. PRO 12 months after breast reconstruction was evaluated using Breast-Q questionnaire. Cosmetic outcome was evaluated by two independent experts by means of pictures taken preoperatively and at the follow-up visits. Results: Breast-Q and 12 months FU were completed by 210 women. Patients without adverse event had a significantly higher Breast-Q score for "sexual well-being" (p = 0.001); "psychosocial well-being" was negatively influenced by prior therapies (p < 0.01), and older patients had significantly lower scores at 12 months FU compared to pre-OP for "satisfaction with breasts" (p < 0.01) while the opposite was true for younger patients. Unilateral surgery resulted in reduced "satisfaction with breast" at 12 months FU (p < 0.01). Radiotherapy negatively influenced "satisfaction with breast", "sexual well-being" and "physical well-being chest". The cosmetic evaluation showed a significant difference (p < 0.001) in the evaluation by the patients and experts with the patients' assessment being worse compared to experts' assessment. Conclusion: Our study showed that two years after implant-based breast reconstruction with support of TiLOOP® Bra PRO is influenced by different factors. This information can be used to improve the decision-making process for women who chose implant-based breast reconstruction.