Concanamycin H from the soil actinomycete Streptomyces sp. R1706-8. Issue 4 (August 2022)

• Record Type: Journal Article
• Authors: Li, Guo-Li; Qi, Hui-Min; He, Yi-Lin; Shen, Yu-Kai; Shen, Tong
• Is Part Of: Journal of chemical research. Volume 46:Issue 4(2022)
• Publication Date: 2022-08
• Subjects: antimicrobial -- concanamycin -- Osmia cornifrons -- secondary metabolites -- Streptomyces; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/17475198221109161
• Languages: English
• ISSNs: 1747-5198

Abstract

The actinomycete strain R1706-8 is isolated from a soil sample collected from the nest of the horned-face bee ( Osmia cornifrons ) and identified as Streptomyces sp. based upon the results of 16SrRNA sequence analysis. Two concanamycin derivatives obtained from the solid fermentation have been determined by analysis of the infrared, high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR spectra as well as by comparison with literature data. Of the two derivatives, one is a new compound, named concanamycin H, and the other is the known compound, concanamycin G. These compounds are assayed for antibacterial activity, with concanamycins H and G displaying inhibitory activity against Bacillus subtilis (minimum inhibitory concentration = 0.625 µg mL −1 ).