Beyond the bipolar disorder diagnosis: Hypothalamus and its network damage in determining neuropsychiatric and Korsakoff-like memory disorders. (May 2021)

• Record Type: Journal Article
• Authors: Ricci, Monica; Ruggeri, Massimiliano; Gerace, Carmela; Brunori, Andrea
• Is Part Of: Cortex. Volume 138(2021)
• Page Start: 178
• Page End: 190
• Publication Date: 2021-05
• Subjects: Craniopharyngioma -- Korsakoff-like amnesia -- Bipolar disorder -- Hypothalamus -- Neuroendoscopic surgery; Neuropsychology -- Periodicals; Nervous system -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Behavior -- Periodicals; Neurology -- Periodicals; 612.825
• DOI: 10.1016/j.cortex.2021.02.004
• Languages: English
• ISSNs: 0010-9452

Abstract

Abstract: Craniopharyngiomas (CP's) are hypothalamic tumors often associated with psychological disorders. Nevertheless, its diagnosis is still challenging when psychiatric disorders are not associated with any other neurological symptoms. This single-case study describes a patient with a history of bipolar disorder before a diagnosis of a large CP arising the sellar and suprasellar region was posed. At the time of the present study the patient showed emotional/behavioral disorders and Korsakoff-like amnesia, that completely recovered after surgical resection of the tumor. This is one of those few cases described in literature, who presented cognitive/behavioral disorders because the compression of the diencephalic structures due to CP mass effect. This case offers further evidence on the functional neuroanatomy of the hypothalamus and its pathways.