Synthesis of α-aminophosphonates by the Kabachnik-Fields reaction. (24th November 2020)

• Record Type: Journal Article
• Authors: Sravya, G.; Balakrishna, A.; Zyryanov, Grigory V.; Mohan, G.; Reddy, C. Suresh; Bakthavatchala Reddy, N.
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 196:Number 4(2021)
• Page Start: 353
• Page End: 381
• Publication Date: 2020-11-24
• Subjects: Synthesis -- α-aminophosphonates -- Kabachnik-Fields reaction; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2020.1854258
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: The review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α-aminophosphonates via Kabachnik-Fields reaction by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These α-aminophosphonates exhibited promising antioxidant, antimicrobial and anticancer activity. Some recent developments on the synthesis of biologically active α-aminophosphonates in the presence of various catalysts, in catalytic solvent medium, in catalyst-free solvent medium, under solvent-free conditions, and reactions in solution are discussed. Miscellaneous reactions are also included. Graphical Abstract: