A Case of Anti-Jo-1 Myositis with Unique Biopsy Findings. (6th June 2022)

• Record Type: Journal Article
• Authors: Zulfiqar, Beenish; Aksionav, Pavel; Bittar, Mohamad; Chapman, Cathy
• Other Names: Koarada Syuichi Academic Editor.
• Is Part Of: Case reports in rheumatology. Volume 2022(2022)
• Publication Date: 2022-06-06
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Case studies -- Periodicals; Rheumatic Diseases; Connective Tissue Diseases; Rheumatology; Periodicals; Electronic journals; Case studies; Periodicals; 616.723
• DOI: 10.1155/2022/9096643
• Languages: English
• ISSNs: 2090-6889

Abstract

Abstract : Antisynthetase syndrome (ASS) or anti-Jo-1 antibody syndrome has a classic clinical presentation including arthritis, myositis, interstitial lung disease, mechanic hands, and/or Raynaud's phenomenon. The biopsy findings are distinctive from polymyositis or dermatomyositis. We describe an interesting case of ASS where a patient presented with significant muscle weakness, proteinuria, and interstitial lung disease. She also had positive Ro-52 antibodies in addition to anti-Jo-1 antibodies. Her biopsy findings were consistent with inflammatory necrotizing myositis.