Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases. (January 2021)

• Record Type: Journal Article
• Authors: Li, Xinnan; Huang, Longjian; Lan, Jiaqi; Feng, Xinhong; Li, Pingping; Wu, Lei; Peng, Ying
• Is Part Of: Pharmacological research. Volume 163(2021)
• Publication Date: 2021-01
• Subjects: Aβ amyloid-β protein -- AC actinonin -- AD Alzheimer's disease -- ALS Amyotrophic lateral sclerosis -- AMPK 5′ adenosine monophosphate–activated protein kinase -- APP amyloid precursor protein -- BNIP3 BCL2 interacting protein 3 -- CK2 casein kinase II -- CL cardiolipin -- CLS CL synthase -- Drp1 dynamin-related protein 1 -- Fis1 fission 1 -- FOXO3 forkhead box O3 -- FUNDC1 FUN14 Domain-Containing Protein 1 -- GABARAP GABAA receptor-associated protein -- GMF glia maturation factor -- HD Huntington's disease -- HIF-1 hypoxia inducible factor-1 -- hIGF-1 human insulin-like growth factor-1 -- IGF-1 insulin-like growth factor-1 -- LAMP1 lysosomal-associated membrane protein 1 -- LC3 microtubule-associated protein light chain 3 -- LDs lipid droplets -- LIR LC3-interacting region -- LRRK2 leucine-rich repeat kinase 2 -- MDVs mitochondria-derived vesicles -- Mff mitochondrial fission factor -- Mfn mitofusin -- mHtt mutant huntingtin -- MiD49 mitochondrial dynamics proteins of 49 kDa -- MiD51 mitochondrial dynamics proteins of 51 kDa -- Miro1 mitochondrial Rho GTPase 1 -- MQC mitochondrial quality control -- mTORC1 mechanistic/mammalian target of rapamycin complex 1 -- MUL1 mitochondrial ubiquitin ligase 1 -- NAM Nicotinamide -- NFTs neurofibrillary tangles -- NIX NIP3-like protein X -- NMN nicotinamide mononucleotide -- NR nicotinamide riboside -- OMM outer mitochondrial membrane -- OPA1 Optic atrophy (Opa) 1 -- OPTN Optineurin -- p62/SQSTM1 Sequestosome 1 -- PD Parkinson's disease -- PGAM5 phosphoglycerate mutase family member 5 -- PI3K phosphoinositide-3-kinase -- PINK1 PTEN induced putative kinase 1 -- Plin4 Perilipin 4 -- PS1 presenilin 1 -- P-tau hyperphosphorylated tau -- PTEN-L phosphatase and tensin homolog (PTEN)-long -- ROS reactive oxygen species -- SARM1 sterile alpha and TIR motif containing 1 -- SNO-Drp1 S-nitrosylation of dynamin-related protein 1 -- SOD1 mutant Cu/Zn superoxide dismutase-1 -- TBK1 Tank Binding Kinase 1 -- TDP-43 TAR DNA-binding protein 43 -- UA urolithin A -- ULK1 unc-51 like autophagy activating kinase 1 -- USP 15 ubiquitin-specific protease 15 -- USP 30 ubiquitin-specific protease 30 -- VCP valosin-containing protein -- VDAC voltage-dependent anion channel; Mitophagy -- Alzheimer's disease (AD) -- Parkinson's disease (PD) -- Huntington's disease (HD) -- Amyotrophic lateral sclerosis (ALS); Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.105240
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Neurodegenerative diseases are the most common diseases of the nervous system in elderly people, which are currently incurable and cause great burden to families and societies. Mitochondria are the energy factory of the cell and have extremely important effects on neuronal function. The elimination of dysfunctional mitochondria is essential for the mitochondrial metabolic homeostasis, energy supply, and neuronal survival. Recent studies suggest that the impaired mitophagy may lead to the accumulation of damaged mitochondria and therefore contribute to the progression of neurodegenerative diseases. This review mainly focuses on mitophagy, mitochondrial dynamics, and their abnormal changes in neurodegenerative diseases, as well as the therapeutic strategies targeting mitophagy that have shown promise in recent preclinical and clinical studies.