Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction. (September 2017)

• Record Type: Journal Article
• Authors: Yan, Youyou; Song, Xinjing; Li, Zhibo; Zhang, Jinpu; Ren, Jiajun; Wu, Junduo; Li, Yali; Guan, Yinuo; Wang, Junnan
• Is Part Of: Biomarkers in medicine. Volume 11:Number 9(2017)
• Page Start: 761
• Page End: 767
• Publication Date: 2017-09
• Subjects: acute myocardial infarction -- apoptosis -- biomarker -- correlation -- ELISA -- granzyme B -- inflammation -- miR-874-3p -- qRT-PCR -- ROC analysis; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm-2017-0144
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: Granzyme B could induce apoptosis of target cell in acute myocardial infarction (AMI) and was identified as the target of miR-874-3p by searching the miRNA database. We aim to determine the levels of granzyme B and miR-874-3p as well as assay their correlations or predict powers in AMI.Patients & methods: We measured levels of plasma granzyme B and miR-874-3p in 80 AMI patients or 40 healthy controls and assayed their correlations or predicted powers for AMI.Results: Elevated levels of granzyme B (16.71 ± 7.23 ng/l vs 9.27 ± 3.90 ng/l) correlated with miR-874-3p downregulation (0.20- ± 0.17-fold vs 1.00- ± 0.79-fold) in AMI patients.Conclusion: Plasma miR-874-3p might target granzyme B and it might be an additional biomarker for AMI.