Meaningful relief with flurbiprofen 8.75 mg spray in patients with sore throat due to upper respiratory tract infection. (March 2018)

• Record Type: Journal Article
• Authors: de Looze, Ferdinandus; Russo, Marc; Bloch, Mark; Montgomery, Barney; Shephard, Adrian; DeVito, Robert
• Is Part Of: Pain management. Volume 8:Number 2(2018)
• Page Start: 79
• Page End: 83
• Publication Date: 2018-03
• Subjects: flurbiprofen -- pharyngitis -- spray; Pain -- Treatment -- Periodicals; 616.047205
• DOI: 10.2217/pmt-2017-0100
• Languages: English
• ISSNs: 1758-1869

Abstract

Aim: Evaluate the efficacy of flurbiprofen 8.75 mg spray for sore throat relief.Patients & methods: Randomized, double-blind study in adults with sore throat due to upper respiratory tract infection who took flurbiprofen (n = 249) or placebo spray (n = 256). Pain relief was assessed using the Sore Throat Relief Rating Scale.Results: Flurbiprofen spray provided significantly greater relief versus placebo from 20 min to 6 h (p < 0.0001; maximum difference: 75 min). Sore throat severity was reduced ≥-2.2 on the Sore Throat Scale from 75 min to 6 h, indicating meaningful relief. Significantly more patients taking flurbiprofen spray reported ≥30 min of 'at least moderate' relief versus placebo over 6 h (p < 0.0001). Most adverse events were mild.Conclusion: Flurbiprofen spray provides rapid, long-lasting and clinically meaningful relief from sore throat (ANZCTR: ACTRN12612000457842).