Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea. Issue 1 (22nd March 2021)

• Record Type: Journal Article
• Authors: Ji, Tingting; Li, Xiaodan; Qiu, Yue; Mei, Lin; Jia, Xinbei; Tai, Jun; Guo, Yongli; Zhang, Jie; Wang, Shengcai; Ni, Xin
• Is Part Of: Pediatric investigation. Volume 5:Issue 1(2021)
• Page Start: 52
• Page End: 57
• Publication Date: 2021-03-22
• Subjects: Obstructive sleep apnea -- Cognitive dysfunction -- Neuropathological mechanisms; Pediatrics -- Periodicals; Pediatrics -- Research -- Periodicals; 618.920005
• DOI: 10.1002/ped4.12247
• Languages: English
• ISSNs: 2574-2272

Abstract

ABSTRACT: Obstructive sleep apnea (OSA) is a common sleep‐disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many studies have focused on OSA‐related characteristics, including intermittent hypoxemia and sleep fragmentation. There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction. This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction. Abstract : Obstructive sleep apnea (OSA) often leads to cognitive dysfunction, however, the underlying mechanisms of this damage remain unclear. In previous studies, a various of researches have been showed that cognitive dysfunction was associated with OSA‐related characteristics and specific neuropathological changes, thus, these findings may provide specific insight into exploring the potential mechanisms.