TBC update: personalized epigenetic management of diabetes. (November 2017)

• Record Type: Journal Article
• Authors: Fodor, Adriana; Cozma, Angela; Karnieli, Eddy
• Is Part Of: Personalized medicine. Volume 14:Number 6(2017)
• Page Start: 531
• Page End: 549
• Publication Date: 2017-11
• Subjects: diabetes -- epigenetic marks -- epigenetics -- personalized care -- personalized management; Pharmacogenomics -- Periodicals; Pharmacogenetics -- Periodicals; 615.19
• DOI: 10.2217/pme-2017-0043
• Languages: English
• ISSNs: 1741-0541

Abstract

The novel genome-wide assays of epigenetic marks have resulted in a greater understanding of how genetics and the environment interact in the development and inheritance of diabetes. Chronic hyperglycemia induces epigenetic changes in multiple organs, contributing to diabetic complications. Specific epigenetic-modifying compounds have been developed to erase these modifications, possibly slowing down the onset of diabetes-related complications. The current review is an update of the previously published paper, describing the most recent advances in the epigenetics of diabetes.