A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years. (April 2018)

• Record Type: Journal Article
• Authors: Moghadam, Azam Rastgar; Mehramiz, Mehrane; Entezari, Malihe; Aboutalebi, Hamideh; Kohansal, Fatemeh; Dadjoo, Parisa; Fiuji, Hamid; Nasiri, Mohammadreza; Aledavood, Seyed Amir; Anvari, Kazem; Simab, Saeideh Ahmadi; Khorrami, Mohammad Sadegh; Moradi, Ali; Hassanian, Seyed Mahdi; Ferns, Gordon A; Sales, Soodabeh Shahid; Avan, Amir
• Is Part Of: Pharmacogenomics. Volume 19:Number 6(2018)
• Page Start: 539
• Page End: 546
• Publication Date: 2018-04
• Subjects: cytochrome p450 -- esophagus squamous cell carcinoma; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2018-0197
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: Esophageal cancer is the eighth most common cancer globally and the seventh most common cause of cancer-related deaths in men. Recent studies have shown that CYP450, family 1, subfamily B, polypeptide 1, which plays a role in the metabolism of xenobiotics, is associated with several cancers. Therefore, in the present study we investigated the association between a genetic variant, CYP1B1 -rs1056836 gene, with the clinical characteristics of patients with squamous cell carcinoma of the esophagus (ESCC).Method: In this study, 117 patients with ESCC and 208 healthy controls were recruited. DNA was extracted and genotyped using real-time PCR-based TaqMan. Kaplan–Meier curves were utilized to assess overall and progression-free survival. To evaluate the relationship between clinicopathological data, genotypic frequencies, disease prognosis and survival, Pearson's χ 2 and t-test were used. Logistic regression was utilized to assess the association between the risk of ESCC and genotypes.Results: The genotypic frequency for GG, GC and CC were 58.6, 29.8 and 11.5%, respectively, in the healthy subjects and 51.8, 36.14 and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found. Also, statistically significant results were not found for this variation and risk of ESCC.Conclusion: Our findings suggest a relationship between the CYP1B1 -rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger populations in different ethnic groups, taking into account potentially important environmental factors such as diet.