The pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants. (April 2018)

• Record Type: Journal Article
• Authors: Allyn-Feuer, Ari; Ade, Alex; Luzum, Jasmine A; Higgins, Gerald A; Athey, Brian D
• Is Part Of: Pharmacogenomics. Volume 19:Number 5(2018)
• Page Start: 413
• Page End: 434
• Publication Date: 2018-04
• Subjects: anticoagulation PGx -- cardiovascular PGx -- GWAS; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0186
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: 'Pharmacoepigenomics' methods informed by omics datasets and pre-existing knowledge have yielded discoveries in neuropsychiatric pharmacogenomics. Now we evaluate the generality of these methods by discovering an extended warfarin pharmacogenomics pathway.Materials & methods: We developed the pharmacoepigenomics informatics pipeline, a scalable multi-omics variant screening pipeline for pharmacogenomics, and conducted an experiment in the genomics of warfarin.Results: We discovered known and novel pharmacogenomics variants and genes, both coding and regulatory, for warfarin response, including adverse events. Such genes and variants cluster in a warfarin response pathway consolidating known and novel warfarin response variants and genes.Conclusion: These results can inform a new warfarin test. The pharmacoepigenomics informatics pipeline may be able to discover new pharmacogenomics markers in other drug-disease systems.