Cyclocondensation versus Cyclocondensation Plus Dehydroxylation During the Reaction of Flavones and Hydrazine. Issue 25 (1st July 2022)

• Record Type: Journal Article
• Authors: Solis, Carlos M.; Salazar, Mario O.; Ramallo, I. Ayelen; García, Paula; Furlan, Ricardo L. E.
• Is Part Of: European journal of organic chemistry. Volume 2022:Issue 25(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-07-01
• Subjects: Dehydroxylation -- Flavone -- Pyrazole -- Tautomerism -- Tyrosinase; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202200455
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A‐ring substitution pattern and propensity to keto enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor. Abstract : Concomitant selective dehydroxylation during the transformation of flavones into pyrazoles with hydrazine is determined by the A‐ring substitution pattern and propensity to keto–enol tautomerization. The obtained pyrazoles show varied tyrosinase inhibition properties, including one nanomolar inhibitor.