The pharmacogenetics of medications used in general anesthesia. (February 2018)

• Record Type: Journal Article
• Authors: Xie, Shangchen; Ma, Wenjuan; Guo, Qulian; Liu, Jie; Li, Wei; McLeod, Howard L; He, Yijing
• Is Part Of: Pharmacogenomics. Volume 19:Number 3(2018)
• Page Start: 285
• Page End: 298
• Publication Date: 2018-02
• Subjects: anesthesia -- pharmacogenetics -- pharmacogenomics -- polymorphisms; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0168
• Languages: English
• ISSNs: 1462-2416

Abstract

General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia induced by drugs including opioids, hypnotic-sedative agents, muscle relaxants and antiemetics. Clinical and genetic factors are reported to influence the efficacy and side effects of these agents. Based on the evidence, clinical action is needed to improve clinical outcomes. This review summarizes the latest knowledge with regards to the pharmacogenetics of anesthetics and general anesthesia related complications.