Anti-Inflammatory Interleukin 10 Inversely Relates to Coronary Atherosclerosis in Persons With Human Immunodeficiency Virus. (11th May 2019)

• Record Type: Journal Article
• Authors: Fourman, Lindsay T; Saylor, Charles F; Cheru, Lediya; Fitch, Kathleen; Looby, Sara; Keller, Kiana; Robinson, Jake A; Hoffmann, Udo; Lu, Michael T; Burdo, Tricia; Lo, Janet
• Is Part Of: Journal of infectious diseases. Volume 221:Number 4(2020)
• Page Start: 510
• Page End: 515
• Publication Date: 2019-05-11
• Subjects: IL-10 -- HIV -- atherosclerosis -- Inflammation; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiz254
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Interleukin 10 (IL-10) is an anti-inflammatory cytokine that may be protective against coronary atherosclerosis. In an observational study of persons with human immunodeficiency virus (PWH) and uninfected controls, IL-10 was measured in serum samples by means of enzyme-linked immunosorbent assay, and coronary atherosclerosis was assessed using computed tomographic angiography. Among PWH, a 10-fold decrease in IL-10 was associated with a 2.6-fold increase in the odds of coronary plaque ( P = .01), after controlling for traditional and nontraditional cardiovascular risk factors. IL-10 was also inversely associated with total coronary plaque (ρ = −0.19; P = .02) and noncalcified coronary plaque (ρ = −0.24; P = .004). Our findings suggest a role for IL-10 in mitigating atherosclerosis in PWH. Clinical Trials Registration . NCT00455793 Abstract : Immune factors that may be atheroprotective in human immunodeficiency virus (HIV) have not been well identified. Our observational study showed an inverse association between anti-inflammatory interleukin 10 and coronary plaque, suggesting that interleukin 10 may help mitigate atherosclerosis in HIV.