Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria. (27th September 2019)

• Record Type: Journal Article
• Authors: Leanse, Leon G; Dong, Pu-Ting; Goh, Xueping S; Lu, Min; Cheng, Ji-Xin; Hooper, David C; Dai, Tianhong
• Is Part Of: Journal of infectious diseases. Volume 221:Number 4(2020)
• Page Start: 618
• Page End: 626
• Publication Date: 2019-09-27
• Subjects: Acinetobacter baumannii -- antimicrobial blue light -- antimicrobial resistance -- Pseudomonas aeruginosa -- quinine; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiz487
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: Antimicrobial resistance is a significant concern to public health, and there is a pressing need to develop novel antimicrobial therapeutic modalities. Methods: In this study, we investigated the capacity for quinine hydrochloride (Q-HCL) to enhance the antimicrobial effects of antimicrobial blue light ([aBL] 405 nm wavelength) against multidrug-resistant (MDR) Gram-negative bacteria in vitro and in vivo. Results: Our findings demonstrated the significant improvement in the inactivation of MDR Pseudomonas aeruginosa and Acinetobacter baumannii (planktonic cells and biofilms) when aBL was illuminated during Q-HCL exposure. Furthermore, the addition of Q-HCL significantly potentiated the antimicrobial effects of aBL in a mouse skin abrasion infection model. In addition, combined exposure of aBL and Q-HCL did not result in any significant apoptosis when exposed to uninfected mouse skin. Conclusions: In conclusion, aBL in combination with Q-HCL may offer a novel approach for the treatment of infections caused by MDR bacteria.