Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls. (January 2018)

• Record Type: Journal Article
• Authors: Randesi, Matthew; van den Brink, Wim; Levran, Orna; Yuferov, Vadim; Blanken, Peter; van Ree, Jan M; Ott, Jurg; Kreek, Mary Jeanne
• Is Part Of: Pharmacogenomics. Volume 19:Number 2(2018)
• Page Start: 95
• Page End: 104
• Publication Date: 2018-01
• Subjects: DBH -- drug addiction -- TH; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2017-0134
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: To determine whether specific dopaminergic system gene variants are associated with opioid dependence.Patients & methods: Subjects included 153 healthy controls, 163 opioid exposed, but not dependent and 281 opioid dependent. Genotypes of 90 variants in 13 genes were examined.Results: The most significant results were obtained for DA β-hydroxylase variants, rs2073837 and rs1611131, which were associated with protection from addiction (q = 0.0172, 0.0415, respectively) and the functional TH variant, rs2070762, was associated with more risk (q = 0.0387). The three variants also showed a combined effect that remained significant after correction for multiple testing (pfinal = 0.0039).Conclusion: These data offer support that dopaminergic gene variants have a role in opioid dependence and warrant further study.