The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development. (15th May 2020)

• Record Type: Journal Article
• Authors: Hosoya, Makoto; Fujioka, Masato; Murayama, Ayako Y.; Okano, Hideyuki; Ogawa, Kaoru
• Is Part Of: FEBS journal. Volume 288:Number 1(2021)
• Page Start: 325
• Page End: 353
• Publication Date: 2020-05-15
• Subjects: cochlea -- common marmoset -- inner ear -- primate; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 572
• DOI: 10.1111/febs.15341
• Languages: English
• ISSNs: 1742-464X

Abstract

Abstract : Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset ( Callithrix jacchus ). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development. Abstract : We investigated cochlear development in a small New World monkey species, the common marmoset ( Callithrix jacchus ). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.