Cationic-bilayered nanoemulsion of fusidic acid: an investigation on eradication of methicillin-resistant Staphylococcus aureus 33591 infection in burn wound. (12th March 2018)

• Record Type: Journal Article
• Authors: Thakur, Kanika; Sharma, Gajanand; Singh, Bhupinder; Jain, Ashay; Tyagi, Rajeev; Chhibber, Sanjay; Katare, Om P
• Is Part Of: Nanomedicine. Volume 13:Number 8(2018)
• Page Start: 825
• Page End: 847
• Publication Date: 2018-03-12
• Subjects: cationic bilayered nanoemulsion -- fusidic acid -- HaCat cell lines -- MRSA 33591 burn wound; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0227
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: The aim of the current study was to investigate the therapeutic efficacy of cationic-charged bilayered nanoemulsion for topical delivery of fusidic acid in eradicating methicillin-resistant Staphylococcus aureus (MRSA) bacterial burn wound infection.Materials & methods: The developed carriers were characterized for particle size, antibacterial activity, cell viability assay in HaCat cell lines, rheological profile, ex vivo and in vivo studies, namely, full thickness MRSA 33591 murine burn wound infection via topical route.Results: The developed cationic bilayered nanogel offered enhanced drug permeation, reduction in bacterial load and enhanced wound contraction along with faster re-epithelialization in burn wounds.Conclusion: The results encourage the exploration of the potential of cationic nanogel in treating resistant microorganisms such as MRSA, especially for application in burn wound infection.