Nanosized carriers based on amphiphilic poly-N-vinyl-2-pyrrolidone for intranuclear drug delivery. (4th May 2018)

• Record Type: Journal Article
• Authors: Luss, Anna L; Kulikov, Pavel P; Romme, Sven B; Andersen, Camilla L; Pennisi, Cristian P; Docea, Anca O; Kuskov, Andrey N; Velonia, Kelly; Mezhuev, Yaroslav O; Shtilman, Mikhail I; Tsatsakis, Aristidis M; Gurevich, Leonid
• Is Part Of: Nanomedicine. Volume 13:Number 7(2018)
• Page Start: 703
• Page End: 715
• Publication Date: 2018-05-04
• Subjects: atomic force microscopy -- curcumin -- fluorescence microscopy -- intranuclear drug delivery -- nanocarrier -- PVP; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0311
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Ability to deliver drugs into the cell nuclei can significantly increase the efficacy of cancer therapies, in particular in the case of multidrug-resistant cancerResults: Polymer nanocarriers based on amphiphilic thiooctadecyl-terminated poly-N-vinyl-2-pyrrolidone were produced and loaded with a model hydrophobic drug, curcumin. Two commonly used loading approaches – emulsification and ultrasonic dispersion – were found to lead to two different size distributions with distinctively different biological effect. While nanocarriers produced via the emulsion method penetrated cells by dynamin-dependent endocytic mechanisms, sub-100 nm dispersion-produced nanocarriers were capable of crossing the membranes via biologically independent mechanisms.Conclusion: This finding opens an intriguing possibility of intranuclear delivery by merely tailoring the size of polymeric carriers, thus promising a new approach for cancer therapies.