The surface chemistry determines the spatio–temporal interaction dynamics of quantum dots in atherosclerotic lesions. (March 2018)

• Record Type: Journal Article
• Authors: Uhl, Bernd; Hirn, Stephanie; Mildner, Karina; Coletti, Raffaele; Massberg, Steffen; Reichel, Christoph A; Rehberg, Markus; Zeuschner, Dagmar; Krombach, Fritz
• Is Part Of: Nanomedicine. Volume 13:Number 6(2018)
• Page Start: 623
• Page End: 638
• Publication Date: 2018-03
• Subjects: atherosclerosis -- in vivo microscopy -- nano–bio interactions -- nanoparticles -- surface chemistry; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0350
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: To optimize the design of nanoparticles for diagnosis or therapy of vascular diseases, it is mandatory to characterize the determinants of nano–bio interactions in vascular lesions.Materials & methods: Using ex vivo and in vivo microscopy, we analyzed the interactive behavior of quantum dots with different surface functionalizations in atherosclerotic lesions of ApoE-deficient mice.Results: We demonstrate that quantum dots with different surface functionalizations exhibit specific interactive behaviors with distinct molecular and cellular components of the injured vessel wall. Moreover, we show a role for fibrinogen in the regulation of the spatio–temporal interaction dynamics in atherosclerotic lesions.Conclusion: Our findings emphasize the relevance of surface chemistry-driven nano–bio interactions on the differential in vivo behavior of nanoparticles in diseased tissue.