Chitosan-coated nanoparticles enhanced lung pharmacokinetic profile of voriconazole upon pulmonary delivery in mice. (31st January 2018)

• Record Type: Journal Article
• Authors: Paul, Paramita; Sengupta, Soma; Mukherjee, Biswajit; Shaw, Tapan K; Gaonkar, Raghuvir H; Debnath, Mita Chatterjee
• Is Part Of: Nanomedicine. Volume 13:Number 5(2018)
• Page Start: 501
• Page End: 520
• Publication Date: 2018-01-31
• Subjects: aerodynamic diameter -- chitosan-coated nanoparticles -- gamma imaging -- lung deposition -- mucoadhesive -- pharmacokinetics -- voriconazole; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0291
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Chitosan-coated polylactic- co -glycolic acid nanoparticles of voriconazole (VChNP) were developed to increase residence time and provide sustained drug release locally to treat recurrent lung-fungal infection.Materials & methods: VChNP has been developed using a simple, unique technique and characterized. Pharmacokinetics, lung deposition with time and gamma imaging were conducted with optimized formulations.Results: The deposition of fluorescein isothiocyanate-labeled VChNP in lung was confirmed by confocal microscopy. Gamma-scintigraphic images showed that Tc-99m-labeled VChNP had better pulmonary retention for longer period than that of noncoated formulation. Drastic improvement in pharmacokinetic profile of VChNP than noncoated formulation was observed.Conclusion: Thus, VChNP may be useful for effective pulmonary delivery with improved bioavailability. Such chitosan-coated nanoparticles may open up a new avenue for efficacious treatment of lung-fungal infection. Graphical abstract: