Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome. (15th May 2020)

• Record Type: Journal Article
• Authors: André, Raphaël; Becker, Minerva; Lombardi, Tommaso; Buchholzer, Samanta; Marchal, Francis; Seebach, Jorg D.
• Is Part Of: Laryngoscope. Volume 131:Number 1(2021)
• Page Start: E83
• Page End: E89
• Publication Date: 2020-05-15
• Subjects: Sjögren's syndrome -- magnetic resonance sialography -- sicca syndrome -- magnetic resonance imaging; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.28742
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Objectives/Hypothesis: To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well‐characterized cohort of patients with primary or secondary Sjögren's syndrome (SS) meeting the American–European Consensus Group criteria. Study Design: Retrospective, observational, monocentric study. Methods: Thirty‐six patients (81% female, mean age = 48 ± 35 years) with primary or secondary SS who underwent MRSIAL were included in the study. Results: MRSIAL revealed characteristic radiological signs in the parotid, sublingual, and submandibular salivary glands in 35/36 patients (97%). Patients presenting with anti‐Sjögren's syndrome–related antigen A (SSA) autoantibodies showed more often fatty infiltration, a "pepper‐and‐salt" appearance, ductal stenosis, and/or ductal dilation of the parotid gland (88%, 88%, and 72% respectively) than patients negative for anti‐SSA (12%, 4%, and 28% respectively). MRSIAL demonstrated signs characteristic of SS in all 11 patients with negative minor salivary gland biopsy. For 15 patients undergoing ultrasound examination only, 11 (73%) had SS findings, but all 15 had SS findings on MRSIAL. Two cases of parotid lymphoma were detected by MRSIAL (6%). Conclusions: MRSIAL is a reliable technique to detect glandular anomalies in patients with SS, and seems to provide a valuable aid in the diagnosis of SS. Level of Evidence: 4 Laryngoscope, 131:E83–E89, 2021