Functional nanocarrier for drug and gene delivery via local administration in mucosal tissues. (January 2018)

• Record Type: Journal Article
• Authors: Wang, Lingwei; Zhou, Yurui; Wu, Menglin; Wu, Minghao; Li, Xue; Gong, Xiaoqun; Chang, Jin; Zhang, Xuening
• Is Part Of: Nanomedicine. Volume 13:Number 1(2018)
• Page Start: 69
• Page End: 88
• Publication Date: 2018-01
• Subjects: drug and gene delivery -- local administration -- mucoadhesive nanoparticles -- mucus -- mucus barrier properties -- mucus-penetrating particles -- nano-delivery system; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0143
• Languages: English
• ISSNs: 1743-5889

Abstract

Local administration has many advantages for treating diseases. However, the surface mucus layer becomes a major obstacle that easily traps and fast removes local administrated drugs and genes in mucosal tissues. Fortunately, the rapidly developing nanocarriers with special physical and chemical properties may help to refine the treatment of mucosal tissues via delivering drugs and genes to the target tissue, and prolong the drug action time. Therefore, this review focuses on the strategies to apply different nanocarriers for drug-delivery in mucosal tissues, including mucoadhesive and mucus-penetrating types. Delivering drugs and genes to anatomical sites with high mucus turnover becomes more feasible and effective, and maintains sufficient local drug concentration to improve treatment efficacy.