Pre‐transplant Social Adaptability Index and clinical outcomes in renal transplantation: The Swiss Transplant Cohort study. Issue 4 (6th March 2021)

• Record Type: Journal Article
• Authors: Denhaerynck, Kris; Goldfarb‐Rumyantzev, Alexander S.; Sandhu, Gurprataap; Beckmann, Sonja; Huynh‐Do, Uyen; Binet, Isabelle; De Geest, Sabina
• Other Names: Brack Gaëlle investigator.; Büttiker Anita investigator.; Künzler Petra investigator.; Leppla Lynn investigator.; Ribaut Janette investigator.; Boehler Annette investigator.; Koller Michael investigator.; Beerli Nadine investigator.; Mauthner Oliver investigator.; Berben Lut investigator.; Merçay Aurélia investigator.; Hadaya Karine investigator.; Seiler Annina investigator.; Dreifuss Joëlle Lynn investigator.; Künzler‐Heule Patrizia investigator.; Burkhalter Hanna investigator.; Struker Marian investigator.; Rothlisberger Christian investigator.; Struker investigator.; Amico Patrizia investigator.; Axel Andres investigator.; Aubert John‐David investigator.; Banz Vanessa investigator.; Beldi Guido investigator.; Benden Christian investigator.; Berger Christoph investigator.; Bochud Pierre‐Yves investigator.; Branca Sanda investigator.; Bucher Heiner investigator.; Carrel Thierry investigator.; Catana Emmanuelle investigator.; Chalandon Yves investigator.; de Rougemont Olivier investigator.; Dickenmann Michael investigator.; Dreifuss Joëlle Lynn investigator.; Duchosal Michel investigator.; Fehr Thomas investigator.; Ferrari‐Lacraz Sylvie investigator.; Garzoni Christian investigator.; Gasche‐Soccal Paola investigator.; Gaudet Christophe investigator.; Giostra Emiliano investigator.; Golshayan Déla investigator.; Hadaya Karine investigator.; Halter Jörg investigator.; Hauri Dimitri investigator.; Heim Dominik investigator.; Hess Christoph investigator.; Hillinger Sven investigator.; Hirsch Hans investigator.; Hirt Patricia investigator.; Hofbauer Günther investigator.; Immer Franz investigator.; Koller Michael investigator.; Laesser Bettina investigator.; Lang Brian investigator.; Lehmann Roger investigator.; Leichtle Alexander investigator.; Lovis Christian investigator.; Manuel Oriol investigator.; Marti Hans‐Peter investigator.; Martin Pierre‐Yves investigator.; Martinelli Michele investigator.; Mellac Katell investigator.; Merçay Aurélia investigator.; Mettler Karin investigator.; Meylan Pascal investigator.; Mueller Nicolas investigator.; Müller Antonia investigator.; Müller Thomas investigator.; Müller‐Arndt Ulrike investigator.; Müllhaupt Beat investigator.; Nägeli Mirjam investigator.; Pascual Manuel investigator.; Posfay‐Barbe Klara investigator.; Rick Juliane investigator.; Rosselet Anne investigator.; Rossi Simona investigator.; Rothlin Silvia investigator.; Ruschitzka Frank investigator.; Schanz Urs investigator.; Schaub Stefan investigator.; Schnyder Aurelia investigator.; Schuurmans Macé investigator.; Simonetta Federico investigator.; Staufer Katharina investigator.; Stampf Susanne investigator.; Steiger Jürg investigator.; Stirnimann Guido investigator.; Toso Christian investigator.; Van Delden Christian investigator.; Venetz Jean‐Pierre investigator.; Villard Jean investigator.; Wick Madeleine investigator.; Wilhlem Markus investigator.; Yerly Patrick investigator.;
• Is Part Of: Clinical transplantation. Volume 35:Issue 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-06
• Subjects: graft survival -- kidney transplantation -- mortality -- socioeconomic factors; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.14218
• Languages: English
• ISSNs: 0902-0063

Abstract

Abstract: Background: The impact of pre‐transplant social determinants of health on post‐transplant outcomes remains understudied. In the United States, poor clinical outcomes are associated with underprivileged status, as assessed by the Social Adaptability Index (SAI), a composite score of education, employment status, marital status, household income, and substance abuse. Using data from the Swiss Transplant Cohort Study (STCS), we determined the SAI's predictive value regarding two post‐transplant outcomes: all‐cause mortality and return to dialysis. Methods: B etween 2012 and 2018, we included adult renal transplant patients (aged ≥ 18 years) with pre‐transplant assessment SAI scores, calculated from a STCS Psychosocial Questionnaire. Time to all‐cause mortality and return to dialysis were predicted using Cox regression. Results: Of 1238 included patients (mean age: 53.8 ± 13.2 years; 37.9% female; median follow‐up time: 4.4 years [IQR: 2.7]), 93 (7.5%) died and 57 (4.6%) returned to dialysis. The SAI's hazard ratio was 0.94 (95%CI: 0.88–1.01; p = .09) for mortality and 0.93 (95%CI: 0.85–1.02; p = .15) for return to dialysis. Conclusions: In contrast to most published studies on social deprivation, analysis of this Swiss sample detected no significant association between SAI score and mortality or return to dialysis.